Synthetic Reactions with Organocopper Reagents.

Transmetalation Reactions Producing Organocopper Reagents

Organocopper reagents constitute a key class of organometallic reagents, with numerous applications in organic synthesis [1]. Their high reactivities and chemoselectivities have made them unique intermediates. Most reports use organocopper reagents of type 1 or 2, which are prepared from organolithiums. This transmetalation procedure confers optimal reactivity, but in many cases it permits only...

Antigen – Antibody Reactions with Labeled Reagents

Reactions of iodine-nitrene reagents with boranes.

Reactions of the boranes (C6F5)2BR (R = C6F5, Ph, H) with the nitrene-iodine reagents XC6H4SO2N=IPh, X = Me, Cl and MeSO2N=IPh effect the insertion of nitrene into the B–C and B–H bonds affording the species (C6F5)2BN(SO2C6H4X)R (X = Me, R = C6F5 1, Ph 3, H, 4, X = Cl, 5, X = NO2, 7) and (C6F5)2BN(SO2Me)H 6).

Organocopper Reagents for the Synthesis of Saturated, and -ethylenic Aldehydes and Ketones

Conjugate addition of organocopper reagents to ct,-ethylenic aldehydes is discussed. Use of cz,r3-ethylenic aminals is an— other approach to the same target, namely homologation of R-M to an aldehyde with three more carbon atoms. The c,-ethylenic aldehydes are easily prepared by carbocupration of c,13-acetylenic acetals. A new way to cz,t3-ethylenic ketones, mediated by organo copper reagents i...

Synthesis of fatty acids using organocopper (I) ate complexes derived from Grignard reagents.

Fatty acid esters have been synthesized in good yield by reaction between copper(I) ate complexes formed from methylcopper(I) and primary or secondary Grignard reagents and esters of primary iodoalkylcarboxylic acids. The synthetic method is i l lustrated with proced.ures for CHr:gH(CHz)rgCO2C2H5, CeHsCHzO(CH2)16COzCzHs, CH3(CH2)25CO2C2H5, CH3O2C(CH)I2CO2CHI, CzHsOzC(CHz)szCO2C2H5, and CHg(CH2)...